Anti-proBDNF Antibody ANT-006 from Alomone Labs, Ltd.

Product Specs
ItemAnti-proBDNF Antibody
CompanyAlomone Labs, Ltd.
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberANT-006
Brand/TrademarkAlomone Labs Ltd
ClonalityPolyclonal
Quantity1 X 25 mcl, 1 X 50 mcl, 1 X 0.2 ml
ApplicationsIF, IHC, IP, WB
FormatReconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3., Lyophilized Powder
Conjugate/TagUnconjugated
ReactivityHuman (Tested);Mouse (Tested);Rat (Tested)
HostRabbit
Antibody TypePrimary
NCBI Gene AliasesANON2, BULN2
Concentration08 mg/ml
PurityAffinity purified on immobilized antigen
IsotypeIgG
ImmunogenSynthetic peptide
Domain/Region/TerminusPro-domain of the BDNF protein
Gene NameBDNF
TargetproBDNF
ValidationAs per applications, See images, contact for clarifications
NCBI Full Gene Namebrain derived neurotrophic factor
pH RangepH 7.4

Specifications/Features

starting price for North American orders, for exact pricing view product page

Sequence

(C)DEDQKVR PNEENNKDAD, corresponding to amino acid residues 72-88 of human BDNF (precursor)

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Alomone Labs, Ltd.

PO Box 4287

Jerusalem 91042

Israel

Phone: +972-2-587-2202
+972-2-587-1101

Company Profile

Website: http://www.alomone.com/

(1) Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic FactorFrontiers in cell and developmental biologyJanuary 1, 2022Hossain MS, Mawatari S, Fujino T.

(2) Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retentionCommunications biologyOctober 5, 2021Vignoli B, Sansevero G, Sasi M, Rimondini R, Blum R, Bonaldo V, Biasini E, Santi S, Berardi N, Lu B, et al.chicken α-proBDNF (Millipore Cat#AB9042; RID:AB#2274709, IHC 1:300), rabbit α-proBDNF (Alomone Labs Cat#ANT-006; RRID:AB_2039758, EM 1:20), rabbit α-BDNFpro (Laboratory of Bai Lu, Govern Institute for Brain Research,

(3) Requirements of Postnatal proBDNF in the Hippocampus for Spatial Memory Consolidation and Neural FunctionFrontiers in Cell and Developmental BiologyJuly 15, 2021Wei Sun, Hong Cheng, Yang Yang, Dongxin Tang, Xiaolian Li, Lei Anrequired. Anti-proBDNF antibody was purchased from Alomone Labs, Ltd. (Jerusalem, Israel; Cat. No. ANT-006). DL-TBOA was purchased from Tocris Cookson (Ellisville, MO, United States). ACSF was purchased from

(4) Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated EncephalopathyFrontiers in neuroscienceJanuary 1, 2021Cui YH, Zhou SF, Liu Y, Wang S, Li F, Dai RP, Hu ZL, Li CQ.incubated with the following primary antibodies overnight at 4°C: anti-proBDNF antibody, catalog no. ANT006, 1:500, Alomone lab; anti-NeuN antibody, 1:1,000, catalog no. ab104224, Abcam; and anti-p75NTR antibody,

(5) Oral quetiapine treatment results in time-dependent alterations of recognition memory and brain-derived neurotrophic factor-related signaling molecules in the hippocampus of ratsPharmacology, biochemistry, and behaviorOctober 1, 2020Poddar I, Callahan PM, Hernandez CM, Pillai A, Yang X, Bartlett MG, Terry AV Jr.

(6) Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor LearningThe Journal of neuroscience : the official journal of the Society for NeuroscienceAugust 12, 2020Andreska T, Rauskolb S, Schukraft N, Lüningschrör P, Sasi M, Signoret-Genest J, Behringer M, Blum R, Sauer M, Tovote P, et al.visualized with a rabbit polyclonal antiserum against the prodomain of human pro-BDNF (Alomone Labs, #ANT-006, RRID:AB_2039758) (Dieni et al., 2012). Presynaptic corticostriatal terminals were labeled with rabbit

(7) Optogenetic Modulation of TrkB Signaling in the Mouse BrainJournal of molecular biologyFebruary 14, 2020Hong J, Heo WD.

(8) Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult MiceASN neuroJanuary 1, 2020Montroull LE, Rothbard DE, Kanal HD, D'Mello V, Dodson V, Troy CM, Zanin JP, Levison SW, Friedman WJ.al., 2008) or pro-brain-derived neurotrophic factor (proBDNF; Alomone Labs, Jerusalem, Israel, Cat# ANT-006, RRID:AB_2039758) were infused intranasally immediately after the surgery, with 2 µl drops to each nostril

(9) Dexmedetomidine Attenuates Neurotoxicity in Developing Rats Induced by Sevoflurane through Upregulating BDNF-TrkB-CREB and Downregulating ProBDNF-P75NRT-RhoA Signaling PathwayMediators of inflammationJanuary 1, 2020Dong Y, Hong W, Tang Z, Gao Y, Wu X, Liu H.

(10) p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual CortexThe Journal of neuroscience : the official journal of the Society for NeuroscienceJune 5, 2019Baho E, Chattopadhyaya B, Lavertu-Jolin M, Mazziotti R, Awad PN, Chehrazi P, Groleau M, Jahannault-Talignani C, Vaucher E, Ango F, et al.chicken anti-proBDNF (Millipore, catalog #AB9042, RRID:AB_2274709), rabbitanti-proBDNF (Alomone Labs, catalog #ANT-006, RRID:AB_2039758), and guinea-pig-anti-proBDNF (Alomone Labs, catalog #AGP-032, RRID:AB_2340967). However,

(11) Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in MiceExperimental neurobiologyApril 1, 2019Choi J, Kim YK, Han PL.6.0 software (MediaCybernetics, Rockville, MD, USA). The primary antibodies used were: anti-proBDNF (ANT-006; 1:1,000, Alomone Labs, Hadassah Ein Kerem, Jerusalem, Israel), BDNF (ab108319; 1:2,000, Abcam, Cambridge,

(12) Increased BDNF-TrkB signaling in the nucleus accumbens plays a role in the risk for psychosis after cannabis exposure during adolescencePharmacology, biochemistry, and behaviorFebruary 1, 2019Dong C, Tian Z, Zhang K, Chang L, Qu Y, Pu Y, Ren Q, Fujita Y, Ohgi Y, Futamura T, et al.

(13) Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell DeathFrontiers in cellular neuroscienceJanuary 1, 2019Montroull LE, Danelon V, Cragnolini AB, Mascó DH.Minneapolis, MN, USA) were infused according to Vaynman et al. (2004), or 0.8 µg/µl anti-proBDNF antibody (cat# ANT-006; Alomone Labs. Jerusalem, Israel) was administered according to Unsain et al. (2009). When the desired

(14) Neuronal RNA-binding protein HuD regulates addiction-related gene expression and behaviorGenes, brain, and behaviorApril 1, 2018Oliver RJ, Brigman JL, Bolognani F, Allan AM, Neisewander JL, Perrone-Bizzozero NI.

(15) Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeysGeroScienceFebruary 1, 2018Robinson AA, Abraham CR, Rosene DL.protein levels, western blot analysis was done using antibodies against (1) proBDNF (Alomone Labs, ANT-006 Lot AN-05), (2) BDNF (Santa Cruz Biotechnology, sc-546), (3) tyrosine kinase receptor B (TrkB) (Millipore,

(16) Pro-BDNF Contributes to Hypoxia/Reoxygenation Injury in Myocardial Microvascular Endothelial Cells: Roles of Receptors p75(NTR) and Sortilin and Activation of JNK and Caspase 3Oxidative medicine and cellular longevityJanuary 1, 2018Yu F, Liu Y, Xu J.

(17) Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative HistochemistryJournal of Histochemistry & CytochemistryMarch 1, 2017Larissa I. Estrada et al.Millipore, Billerica, MA #4604; Cell Signaling Technology, Danvers, MA #385911, lot D00155144; Millipore ANT-006, lot AN-05; Alomone Labs, Jerusalem, Israel Abbreviations: NeuN, neuronal nuclei; PV, parvalbumin;

(18) Behavioral and biochemical effects of ketamine and dextromethorphan relative to its antidepressant-like effects in Swiss Webster miceNeuroreportSeptember 28, 2016Nguyen L, Lucke-Wold BP, Logsdon AF, Scandinaro AL, Huber JD, Matsumoto RR.and then with the appropriate primary antibodies overnight at 4° C (rabbit antipro-BDNF catalog no. ANT006, 1:600, Alomone Labs, Jerusalem, Israel; rabbit anti-BDNF catalog no. ANT010, 1:200, Alomone Labs; or

(19) Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processesMolecular and cellular neurosciencesSeptember 1, 2016Danelon V, Montroull LE, Unsain N, Barker PA, Mascó DH.

(20) BDNF pro-peptide regulates dendritic spines via caspase-3Cell death & diseaseJune 16, 2016Guo J, Ji Y, Ding Y, Jiang W, Sun Y, Lu B, Nagappan G.reports described the presence of BDNF pro-peptide in rodent brain using either a rabbit polyclonal (ANT-006 from Alomone Labs, Hadassah Ein Kerem, Jerusalem, Israel) or a mouse monoclonal antibody (mAb287) raised

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